ISY1 - ISY1 splicing factor homolog Gene

Also Known as FSAP33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57461

About ISY1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:129,127,415-129,161,063 (from NCBI)

This gene has 7 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in bone marrow (RPKM 10.5), lymph node (RPKM 7.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type catalytic step 1 spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

ISY1 Products (2)

mRNA Protein Name
NM_001199469.2 NP_001186398.1 pre-mRNA-splicing factor ISY1 homolog isoform 1
NM_020701.4 NP_065752.1 pre-mRNA-splicing factor ISY1 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
29301961 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type catalytic step 1 spliceosome IDA
IDA: Inferred from direct assay
29301961 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29301961 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISY1 Protein Structure

Isy1

Isy1: Isy1-like splicing family (1 - 267)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

pre-mRNA-splicing factor ISY1 homolog

  • functional spliceosome-associated protein 33

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06941 ISY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ISY1 MGD MGI:1923310
Rattus norvegicus ISY1 RGD RGD:1307688
Others ISY1 NCBI