PLEKHG1 - pleckstrin homology and RhoGEF domain containing G1 Gene

Also Known as ARHGEF41

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57480

About PLEKHG1

This gene has 9 transcripts (splice variants), 210 orthologues and 22 paralogues. Broad expression in spleen (RPKM 8.2), lymph node (RPKM 3.6) and 21 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHG1 Products (10)

mRNA Protein Name
NM_001029884.3 NP_001025055.1 pleckstrin homology domain-containing family G member 1 isoform c
NM_001329798.2 NP_001316727.1 pleckstrin homology domain-containing family G member 1 isoform a
NM_001329799.2 NP_001316728.1 pleckstrin homology domain-containing family G member 1 isoform b
NM_001329800.2 NP_001316729.1 pleckstrin homology domain-containing family G member 1 isoform c
NM_001329801.2 NP_001316730.1 pleckstrin homology domain-containing family G member 1 isoform c
NM_001329802.2 NP_001316731.1 pleckstrin homology domain-containing family G member 1 isoform d
NM_001329803.2 NP_001316732.1 pleckstrin homology domain-containing family G member 1 isoform e
NM_001329804.2 NP_001316733.1 pleckstrin homology domain-containing family G member 1 isoform f
NM_001329805.2 NP_001316734.1 pleckstrin homology domain-containing family G member 1 isoform f
NM_001329806.2 NP_001316735.1 pleckstrin homology domain-containing family G member 1 isoform f

PLEKHG1 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (117 - 292)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1385 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family G member 1

  • pleckstrin homology domain containing, family G (with RhoGef domain) member 1

Related Diseases

Diseases Alias
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10689 PLEKHG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLEKHG1 VGNC VGNC:83445
Mus musculus PLEKHG1 MGD MGI:2676551
Felis catus PLEKHG1 VGNC VGNC:64226
Rattus norvegicus PLEKHG1 RGD RGD:1583676
Canis familiaris PLEKHG1 VGNC VGNC:44676
Bos taurus PLEKHG1 VGNC VGNC:33014