CRACD - capping protein inhibiting regulator of actin dynamics Gene

Homo sapiens

Also known as CRAD; KIAA1211

Gene ID: 57482 | Gene type: protein coding

About CRACD

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,049,098-56,330,609 (from NCBI)

This gene has 10 transcripts (splice variants) and 177 orthologues. Biased expression in testis (RPKM 12.2), small intestine (RPKM 8.0) and 13 other tissues.

Summary

Involved in negative regulation of barbed-end actin filament capping. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CRACD Products(6)

mRNA	Protein	Name
NM_001393381.1	NP_001380310.1	capping protein-inhibiting regulator of actin dynamics isoform 1
NM_001393382.1	NP_001380311.1	capping protein-inhibiting regulator of actin dynamics isoform 1
NM_001393383.1	NP_001380312.1	capping protein-inhibiting regulator of actin dynamics isoform 2
NM_001393384.1	NP_001380313.1	capping protein-inhibiting regulator of actin dynamics isoform 2
NM_001393385.1	NP_001380314.1	capping protein-inhibiting regulator of actin dynamics isoform 2
NM_020722.2	NP_065773.1	capping protein-inhibiting regulator of actin dynamics isoform 1

CRACD Protein Structure

DUF4592

0
200
400
600
800
1000
1233 a.a.

Protein Preferred Names

Protein Names

capping protein-inhibiting regulator of actin dynamics

cancer-related regulator of actin dynamics

Related Diseases

Diseases

Alias

Testicular Leydig Cell Tumor

Testicular Leydig Cell Neoplasm	Leydig Cell Tumor Of Testis
Interstitial Cell Neoplasm Of Testis

Testicular Sex Cord-Stromal Neoplasm

Sex Cord-Stromal Tumor Of Testis

Testicular Sex Cord-Stromal Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03136	CRACD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CRACD	RGD	RGD:1311575
Macaca mulatta	CRACD	VGNC	VGNC:73935
Mus musculus	CRACD	MGD	MGI:2444817
Bos taurus	CRACD	VGNC	VGNC:59341
Felis catus	CRACD	VGNC	VGNC:63093

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