CRACD - capping protein inhibiting regulator of actin dynamics Gene

Also Known as CRAD; KIAA1211

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57482

About CRACD

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,049,098-56,330,609 (from NCBI)

This gene has 10 transcripts (splice variants) and 177 orthologues. Biased expression in testis (RPKM 12.2), small intestine (RPKM 8.0) and 13 other tissues.

Summary

Involved in negative regulation of barbed-end actin filament capping. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CRACD Products (6)

mRNA Protein Name
NM_001393381.1 NP_001380310.1 capping protein-inhibiting regulator of actin dynamics isoform 1
NM_001393382.1 NP_001380311.1 capping protein-inhibiting regulator of actin dynamics isoform 1
NM_001393383.1 NP_001380312.1 capping protein-inhibiting regulator of actin dynamics isoform 2
NM_001393384.1 NP_001380313.1 capping protein-inhibiting regulator of actin dynamics isoform 2
NM_001393385.1 NP_001380314.1 capping protein-inhibiting regulator of actin dynamics isoform 2
NM_020722.2 NP_065773.1 capping protein-inhibiting regulator of actin dynamics isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30361697 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of barbed-end actin filament capping IDA
IDA: Inferred from direct assay
30361697 GOA
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
30361697 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRACD Protein Structure

DUF4592

DUF4592: Domain of unknown function (DUF4592) (45 - 173)

  • 0
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  • 1000
  • 1233 a.a.
Protein Preferred Names Protein Names

capping protein-inhibiting regulator of actin dynamics

  • cancer-related regulator of actin dynamics

Related Diseases

Diseases Alias
Testicular Leydig Cell Tumor

  • Testicular Leydig Cell Neoplasm

  • Leydig Cell Tumor Of Testis

  • Interstitial Cell Neoplasm Of Testis
Testicular Sex Cord-Stromal Neoplasm

  • Sex Cord-Stromal Tumor Of Testis

  • Testicular Sex Cord-Stromal Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03136 CRACD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CRACD RGD RGD:1311575
Macaca mulatta CRACD VGNC VGNC:73935
Mus musculus CRACD MGD MGI:2444817
Bos taurus CRACD VGNC VGNC:59341
Felis catus CRACD VGNC VGNC:63093
Others CRACD NCBI