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SORCS2 - sortilin related VPS10 domain containing receptor 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57537

About SORCS2

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,192,538-7,742,827 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 4 paralogues. Broad expression in brain (RPKM 4.7), kidney (RPKM 2.0) and 20 other tissues.

Summary

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing Receptor Proteins. The VPS10 domain name comes from the yeast Carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]

SORCS2 Products (1)

mRNA	Protein	Name
NM_020777.3	NP_065828.2	VPS10 domain-containing receptor SorCS2 precursor

SORCS2 Protein Structure

PKD

0
200
400
600
800
1000
1159 a.a.

Protein Preferred Names	Protein Names
VPS10 domain-containing receptor SorCS2	VPS10 domain receptor protein

SORCS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89579	SorCS2 Antibody (YA8923)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 51	DFNB51 Autosomal Recessive Nonsyndromic Deafness 51 Autosomal Recessive Deafness 51
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13571	SORCS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SORCS2	VGNC	VGNC:77933
Bos taurus	SORCS2	VGNC	VGNC:59367
Felis catus	SORCS2	VGNC	VGNC:65572
Rattus norvegicus	SORCS2	RGD	RGD:1310621
Canis familiaris	SORCS2	VGNC	VGNC:46660
Mus musculus	SORCS2	MGD	MGI:1932289