JCAD - junctional cadherin 5 associated Gene

Also Known as KIAA1462

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57608

About JCAD

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,012,803-30,115,494 (from NCBI)

This gene has 3 transcripts (splice variants) and 124 orthologues. Broad expression in fat (RPKM 28.1), lung (RPKM 20.0) and 17 other tissues.

Summary

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]

JCAD Products (4)

mRNA Protein Name
NM_001350001.2 NP_001336930.1 junctional cadherin 5-associated protein isoform 2
NM_001350021.2 NP_001336950.1 junctional cadherin 5-associated protein isoform 2
NM_001350022.2 NP_001336951.1 junctional cadherin 5-associated protein isoform 1
NM_020848.4 NP_065899.1 junctional cadherin 5-associated protein isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
28705794 GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
28705794 GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
28705794 GOA
involved in positive regulation of vascular endothelial growth factor signaling pathway IMP
IMP: Inferred from mutant phenotype
28705794 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
28705794 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
28705794 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
28705794 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JCAD Protein Structure

JCAD

JCAD: Junctional protein associated with coronary artery disease (1 - 1348)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1359 a.a.
Protein Preferred Names Protein Names

junctional cadherin 5-associated protein

  • junctional protein associated with coronary artery disease

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07032 JCAD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris JCAD VGNC VGNC:42183
Bos taurus JCAD VGNC VGNC:56189
Mus musculus JCAD MGD MGI:2685174
Felis catus JCAD VGNC VGNC:63003
Rattus norvegicus JCAD RGD RGD:1562037
Macaca mulatta JCAD VGNC VGNC:73937
Others JCAD NCBI