ZFAT - zinc finger and AT-hook domain containing Gene

Also Known as AITD3; ZFAT1; ZNF406

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57623

About ZFAT

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:134,477,788-134,832,339 (from NCBI)

This gene has 17 transcripts (splice variants), 203 orthologues, 38 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 4.4), kidney (RPKM 1.1) and 17 other tissues.

Summary

This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in Apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

ZFAT Products (6)

mRNA Protein Name
NM_001029939.4 NP_001025110.2 zinc finger protein ZFAT isoform 2
NM_001167583.3 NP_001161055.1 zinc finger protein ZFAT isoform 2
NM_001174157.2 NP_001167628.1 zinc finger protein ZFAT isoform 3
NM_001174158.2 NP_001167629.1 zinc finger protein ZFAT isoform 4
NM_001289394.2 NP_001276323.1 zinc finger protein ZFAT isoform 2
NM_020863.4 NP_065914.2 zinc finger protein ZFAT isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
36162510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFAT Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (117 - 135)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (285 - 307)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (313 - 335)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (404 - 426)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (432 - 454)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (458 - 481)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (743 - 764)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (770 - 793)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (830 - 853)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (895 - 918)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (939 - 959)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (966 - 988)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (994 - 1018)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1042 - 1064)

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  • 1000
  • 1243 a.a.
Protein Preferred Names Protein Names

zinc finger protein ZFAT

  • zinc finger gene in autoimmune thyroid disease

Related Diseases

Diseases Alias
Autoimmune Thyroid Disease 3

  • Autoimmune Thyroid Disease, Susceptibility To, 3

  • AITD3

  • Autoimmune Thyroid Disease, Susceptibility To 3

  • Thyroid Disease, Autoimmune, Susceptibility To, Type 3
Croup

  • Acute Obstructive Laryngitis

  • Laryngotracheobronchitis

  • Acute Laryngotracheobronchitis

  • Croup Syndrome

  • Acute Laryngitis With Obstruction

  • Obstructive Laryngitis

  • Obstructive Laryngitis Nos

  • Obstructive Laryngotracheitis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16033 ZFAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZFAT VGNC VGNC:37154
Mus musculus ZFAT MGD MGI:2681865
Felis catus ZFAT VGNC VGNC:67227
Macaca mulatta ZFAT VGNC VGNC:79209
Rattus norvegicus ZFAT RGD RGD:1310886
Canis familiaris ZFAT VGNC VGNC:48604
Others ZFAT NCBI