ARHGAP23 - Rho GTPase activating protein 23 Gene
Species: Homo sapiens
About ARHGAP23
This gene has 12 transcripts (splice variants), 1 gene allele, 201 orthologues and 1 paralogue. Broad expression in skin (RPKM 13.7), brain (RPKM 13.2) and 22 other tissues.
Summary
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
ARHGAP23 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199417.2 | NP_001186346.1 | rho GTPase-activating protein 23 |
ARHGAP23 Protein Structure
PDZ: PDZ domain (Also known as DHR or GLGF) (95 - 152)
PH_9: Pleckstrin homology domain (691 - 803)
RhoGAP: RhoGAP domain (920 - 1070)
- 0
- 300
- 600
- 900
- 1200
- 1491 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
rho GTPase-activating protein 23 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Parainfluenza Virus Type 3 |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS00923 | ARHGAP23 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | ARHGAP23 | MGD | MGI:3697726 |
| Macaca mulatta | ARHGAP23 | VGNC | VGNC:99116 |
| Felis catus | ARHGAP23 | VGNC | VGNC:59880 |
| Canis familiaris | ARHGAP23 | VGNC | VGNC:38052 |
| Rattus norvegicus | ARHGAP23 | RGD | RGD:1309742 |
| Bos taurus | ARHGAP23 | VGNC | VGNC:55773 |
| Others | ARHGAP23 | NCBI |
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