2. Gene
  3. ARHGAP23 - Rho GTPase activating protein 23 Gene

ARHGAP23 - Rho GTPase activating protein 23 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57636 | Gene type: protein coding

About ARHGAP23

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,419,275-38,512,385 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 201 orthologues and 1 paralogue. Broad expression in skin (RPKM 13.7), brain (RPKM 13.2) and 22 other tissues.

Summary

The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]

ARHGAP23 Products(1)

mRNA Protein Name
NM_001199417.2 NP_001186346.1 rho GTPase-activating protein 23

ARHGAP23 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (95 - 152)

PH_9

PH_9: Pleckstrin homology domain (691 - 803)

RhoGAP

RhoGAP: RhoGAP domain (920 - 1070)

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  • 1491 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 23

rho-type GTPase-activating protein 23

Related Diseases

Diseases Alias
Parainfluenza Virus Type 3

Human Parainfluenza Virus Type 3

Piv3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00923 ARHGAP23 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARHGAP23 MGD MGI:3697726
Macaca mulatta ARHGAP23 VGNC VGNC:99116
Felis catus ARHGAP23 VGNC VGNC:59880
Canis familiaris ARHGAP23 VGNC VGNC:38052
Rattus norvegicus ARHGAP23 RGD RGD:1309742
Bos taurus ARHGAP23 VGNC VGNC:55773