USP37 - ubiquitin specific peptidase 37 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57695

About USP37

This gene has 11 transcripts (splice variants), 205 orthologues and 71 paralogues. Broad expression in testis (RPKM 8.0), small intestine (RPKM 5.9) and 25 other tissues.

Summary

Enables cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent Deubiquitinase. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP37 Products (1)

mRNA Protein Name
NM_020935.3 NP_065986.3 ubiquitin carboxyl-terminal hydrolase 37

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
21596315 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21596315 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21596315 GOA
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
21596315 GOA
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
21596315 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
21596315 GOA
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
27296872 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
27296872 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP37 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (341 - 948)

UIM

UIM: Ubiquitin interaction motif (703 - 716)

UIM

UIM: Ubiquitin interaction motif (806 - 822)

UIM

UIM: Ubiquitin interaction motif (828 - 844)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 979 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 37

  • deubiquitinating enzyme 37

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15548 USP37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20511 Usp37 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27020 Usp37 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP37 VGNC VGNC:36726
Macaca mulatta USP37 VGNC VGNC:79220
Rattus norvegicus USP37 RGD RGD:2319715
Mus musculus USP37 MGD MGI:2442483
Canis familiaris USP37 VGNC VGNC:48192
Felis catus USP37 VGNC VGNC:66883
Others USP37 NCBI