WDFY4 - WDFY family member 4 Gene

Also Known as C10orf64

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57705

About WDFY4

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:48,684,873-48,982,956 (from NCBI)

This gene has 6 transcripts (splice variants), 254 orthologues and 7 paralogues. Biased expression in lymph node (RPKM 13.1), spleen (RPKM 9.3) and 10 other tissues.

Summary

Predicted to be involved in Autophagy. Predicted to act upstream of or within with a positive effect on CD8-positive, alpha-beta T cell activation. Predicted to act upstream of or within antigen processing and presentation and cellular response to virus. Predicted to be located in early endosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

WDFY4 Products (4)

mRNA Protein Name
NM_001370153.1 NP_001357082.1 WD repeat- and FYVE domain-containing protein 4 isoform 2
NM_001370154.1 NP_001357083.1 WD repeat- and FYVE domain-containing protein 4 isoform 3
NM_001394531.1 NP_001381460.1 WD repeat- and FYVE domain-containing protein 4 isoform 1
NM_020945.2 NP_065996.1 WD repeat- and FYVE domain-containing protein 4 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDFY4 Protein Structure

PH_BEACH

PH_BEACH: PH domain associated with Beige/BEACH (2455 - 2507)

Beach

Beach: Beige/BEACH domain (2540 - 2821)

WD40

WD40: WD domain, G-beta repeat (2976 - 3010)

WD40

WD40: WD domain, G-beta repeat (3065 - 3100)

  • 0
  • 500
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  • 2500
  • 3000
  • 3184 a.a.
Protein Preferred Names Protein Names

WD repeat- and FYVE domain-containing protein 4

Related Diseases

Diseases Alias
Myasthenic Syndrome, Congenital, 6, Presynaptic

  • Familial Infantile Myasthenia

  • CMS6

  • Cmsea

  • Congenital Myasthenic Syndrome 6

  • Familial Infantile Myasthenia Gravis 2

  • Fimg2

  • Myasthenic Syndrome, Congenital, Associated With Episodic Apnea

  • Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea

  • Congenital Myasthenic Syndrome Type Ia2, Formerly

  • Cms1a2, Formerly

  • Cms Ia2, Formerly

  • Myasthenia, Familial Infantile, Formerly

  • Fim, Formerly

  • Myasthenia Gravis, Familial Infantile, 2, Formerly

  • Fimg2, Formerly

  • Cms Ia2

  • Cms1a2

  • Congenital Myasthenic Syndrome 6, Presynaptic

  • Congenital Myasthenic Syndrome Type Ia2

  • Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea

  • Fim

  • Cms1a

  • Cms-Ea

  • Cms Ia

  • Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea

  • Congenital Myasthenic Syndrome Type 1a

  • Congenital Myasthenic Syndrome Type Ia

  • Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15757 WDFY4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus WDFY4 MGD MGI:3584510
Rattus norvegicus WDFY4 RGD RGD:1564142
Canis familiaris WDFY4 VGNC VGNC:53018
Macaca mulatta WDFY4 VGNC VGNC:106120
Felis catus WDFY4 VGNC VGNC:109517
Bos taurus WDFY4 VGNC VGNC:55999
Others WDFY4 NCBI