Piwil1 - piwi-like RNA-mediated gene silencing 1 Gene

Also Known as MIWI

Species: Mus musculus

Gene Type: protein coding

Gene ID: 57749

Summary

Enables several functions, including RNA binding activity; mRNA cap binding complex binding activity; and polysome binding activity. Involved in negative regulation of transposition; piRNA metabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in chromatoid body; dense body; and nucleus. Is expressed in genitourinary system. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1). [provided by Alliance of Genome Resources, Apr 2022]

Piwil1 Products (1)

mRNA	Protein	Name
NM_021311.3	NP_067286.1	piwi-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	22121019	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	12062093	MGI
enables mRNA cap binding complex binding	IDA IDA: Inferred from direct assay	16938833	MGI
enables piRNA binding	IDA IDA: Inferred from direct assay	16751776	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16787948	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22205278	MGI
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	11578866	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within pachytene	IGI IGI: Inferred from genetic interaction	21539824	MGI
acts upstream of or within pachytene	IMP IMP: Inferred from mutant phenotype	21539824	MGI
involved in piRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	24787618	MGI
involved in piRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	25582079	MGI
involved in piRNA-mediated retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	22121019	MGI
involved in primary piRNA processing	IMP IMP: Inferred from mutant phenotype	22121019	MGI
involved in sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	28552346	MGI
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	12062093	MGI
involved in spermatogenesis	EXP EXP: Inferred from Experiment	24787618	MGI
involved in spermatogenesis	IDA IDA: Inferred from direct assay	23328397	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	12062093	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	22121019	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatoid body	IDA IDA: Inferred from direct assay	16787948	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11578866	MGI
located in dense body	IDA IDA: Inferred from direct assay	21539824	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21539824	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
piwi-like protein 1	piwi-like homolog 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10584	PIWIL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Piwil1	NCBI	NCBI:9271