2. Gene
  3. Ttyh1 - tweety family member 1 Gene

Ttyh1 - tweety family member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as tty; TTY1; mTTY1; 4930459B04Rik; 6330408P11Rik

Gene ID: 57776 | Gene type: protein coding

About Ttyh1

Summary

This gene encodes a member of the Tweety family of membrane proteins. Members of this family contain five predicted transmembrane regions that are arranged in a characteristic pattern. In mouse, the protein is predominantly localized to the endoplasmic reticulum and displays calcium binding activity. Targeted knock out of this gene results in early embryonic lethality prior to the blastocyst stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Ttyh1 Products(4)

mRNA Protein Name
NM_001001454.4 NP_001001454.2 protein tweety homolog 1 isoform 1
NM_001109765.2 NP_001103235.1 protein tweety homolog 1 isoform 2
NM_001305822.1 NP_001292751.1 protein tweety homolog 1 isoform 3
NM_021324.6 NP_067299.2 protein tweety homolog 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
20634317 MGI
enables volume-sensitive chloride channel activity IDA
IDA: Inferred from direct assay
31138989 MGI
Biological Process GO Annotation Evidence Reference Source
involved in L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
31138989 MGI
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
31079925 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
31079925 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
17116230 MGI
acts upstream of or within cell-substrate adhesion IDA
IDA: Inferred from direct assay
17116230 MGI
acts upstream of or within filopodium assembly IDA
IDA: Inferred from direct assay
17116230 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
31079925 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20568244 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
31079925 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
31079925 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
31079925 MGI
Cellular Component GO Annotation Evidence Reference Source
located in filopodium membrane IDA
IDA: Inferred from direct assay
17116230 MGI
located in filopodium tip IDA
IDA: Inferred from direct assay
17116230 MGI
is active in membrane IDA
IDA: Inferred from direct assay
31079925 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
31138989 MGI
located in smooth endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
20568244 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16635246 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16635246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein tweety homolog 1

tweety homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15241 TTYH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttyh1 NCBI NCBI:57348