PTBP2 - polypyrimidine tract binding protein 2 Gene

Also Known as nPTB; PTBLP; brPTB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58155

About PTBP2

Cytogenetic location: 1p21.3 Genomic coordinates (GRCh38): 1:96,721,784-96,823,739 (from NCBI)

This gene has 19 transcripts (splice variants), 277 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.6), brain (RPKM 9.8) and 24 other tissues.

Summary

The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of Other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

PTBP2 Products (8)

mRNA Protein Name
NM_001300985.2 NP_001287914.1 polypyrimidine tract-binding protein 2 isoform 1
NM_001300986.2 NP_001287915.1 polypyrimidine tract-binding protein 2 isoform 2
NM_001300987.2 NP_001287916.1 polypyrimidine tract-binding protein 2 isoform 3
NM_001300988.2 NP_001287917.1 polypyrimidine tract-binding protein 2 isoform 4
NM_001300989.2 NP_001287918.1 polypyrimidine tract-binding protein 2 isoform 5
NM_001300990.2 NP_001287919.1 polypyrimidine tract-binding protein 2 isoform 7
NM_001410833.1 NP_001397762.1 polypyrimidine tract-binding protein 2 isoform 8
NM_021190.4 NP_067013.1 polypyrimidine tract-binding protein 2 isoform 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26871637 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of RNA splicing IDA
IDA: Inferred from direct assay
18335065 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTBP2 Protein Structure

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (78 - 131)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (197 - 255)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (355 - 410)

(457 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

polypyrimidine tract-binding protein 2

  • PTB-like protein

PTBP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83157 PTBP2 Antibody (YA2902) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Patellar Tendinitis

  • Patellar Tendonitis
Adenoiditis

  • Chronic Adenoiditis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11352 PTBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTBP2 MGD MGI:1860489
Felis catus PTBP2 VGNC VGNC:64421
Macaca mulatta PTBP2 VGNC VGNC:76280
Bos taurus PTBP2 VGNC VGNC:55667
Rattus norvegicus PTBP2 RGD RGD:1359267
Canis familiaris PTBP2 VGNC VGNC:54061
Others PTBP2 NCBI