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Sall1 - spalt like transcription factor 1 Gene

Also Known as Msal-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 58198

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of ectoderm development; negative regulation of mesoderm development; and nephron epithelium morphogenesis. Acts upstream of or within several processes, including limb morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Part of NuRD complex. Is expressed in several structures, including autopod; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Used to study Townes-Brocks syndrome. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome and middle lobe syndrome. Orthologous to human SALL1 (spalt like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sall1 Products (3)

mRNA	Protein	Name
NM_001371069.1	NP_001357998.1	sal-like protein 1
NM_001371070.1	NP_001357999.1	sal-like protein 1
NM_021390.3	NP_067365.2	sal-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19168674	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21062744	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21062744	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20439720	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21062744	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11836251	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16707490	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of GABAergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	18024993	MGI
acts upstream of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	24550112	MGI
involved in branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	12482961	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	18470945	MGI
acts upstream of or within forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	19168674	MGI
acts upstream of or within hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	19168674	MGI
acts upstream of or within inductive cell-cell signaling	IMP IMP: Inferred from mutant phenotype	11688560	MGI
involved in kidney epithelium development	IMP IMP: Inferred from mutant phenotype	16839447	MGI
acts upstream of or within mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	24550112	MGI
acts upstream of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP IMP: Inferred from mutant phenotype	24550112	MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP IMP: Inferred from mutant phenotype	11688560	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16707490	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18470945	MGI
involved in negative regulation of ectoderm development	IMP IMP: Inferred from mutant phenotype	21062744	MGI
acts upstream of or within negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP IMP: Inferred from mutant phenotype	24550112	MGI
involved in negative regulation of mesoderm development	IMP IMP: Inferred from mutant phenotype	21062744	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	19168674	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11836251	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16707490	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19168674	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18470945	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	16790473	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	18818376	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18024993	MGI
acts upstream of or within olfactory bulb development	IMP IMP: Inferred from mutant phenotype	18024993	MGI
involved in olfactory bulb interneuron differentiation	IMP IMP: Inferred from mutant phenotype	18024993	MGI
acts upstream of or within olfactory nerve development	IMP IMP: Inferred from mutant phenotype	18024993	MGI
involved in olfactory nerve development	IMP IMP: Inferred from mutant phenotype	18024993	MGI
acts upstream of or within positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	24550112	MGI
acts upstream of or within positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18024993	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20439720	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20439720	MGI
acts upstream of or within regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	18024993	MGI
acts upstream of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	19168674	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20439720	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	11688560	MGI
acts upstream of or within ureteric bud invasion	IMP IMP: Inferred from mutant phenotype	16839447	MGI
involved in ureteric bud invasion	IMP IMP: Inferred from mutant phenotype	11688560	MGI
acts upstream of or within ventricular septum development	IGI IGI: Inferred from genetic interaction	16790473	MGI
involved in ventricular septum development	IMP IMP: Inferred from mutant phenotype	18470945	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	11836251	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	17295837	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11688560	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sal-like protein 1	sal-3 sal-like 1 zinc finger protein Spalt-3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12417	SALL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sall1	NCBI	NCBI:6299