2. Gene
  3. Nelfb - negative elongation factor complex member B Gene

Nelfb - negative elongation factor complex member B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cobra1; Nelf-b; A730008L03Rik

Gene ID: 58202 | Gene type: protein coding

About Nelfb

Summary

This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Nelfb Products(2)

mRNA Protein Name
NM_001310157.1 NP_001297086.1 negative elongation factor B isoform 2
NM_021393.3 NP_067368.3 negative elongation factor B isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
26010750 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
25773599 MGI
involved in negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
19340312 MGI
involved in negative regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19340312 MGI
involved in stem cell differentiation IMP
IMP: Inferred from mutant phenotype
25773599 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

negative elongation factor B

cofactor of BRCA1

negative elongation factor complex member B, Cobra1

ortholog of human cofactor of BRCA1 (COBRA1)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09202 NELFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nelfb NCBI NCBI:25920