PWP2 - PWP2 small subunit processome component Gene

Also Known as UTP1; PWP2H; EHOC-17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5822

About PWP2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,107,399-44,131,181 (from NCBI)

This gene has 6 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in lymph node (RPKM 6.5), spleen (RPKM 6.3) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be located in nucleoplasm. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. [provided by Alliance of Genome Resources, Apr 2022]

PWP2 Products (1)

mRNA Protein Name
NM_005049.3 NP_005040.2 periodic tryptophan protein 2 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30021884 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PWP2 Protein Structure

WD40

WD40: WD domain, G-beta repeat (369 - 401)

WD40

WD40: WD domain, G-beta repeat (407 - 443)

WD40

WD40: WD domain, G-beta repeat (493 - 529)

Utp12

Utp12: Dip2/Utp12 Family (770 - 876)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 919 a.a.
Protein Preferred Names Protein Names

periodic tryptophan protein 2 homolog

  • PWP2 periodic tryptophan protein homolog

Related Diseases

Diseases Alias
Holoprosencephaly 1

  • Arhinencephaly

  • HPE1

  • Cyclopia

  • Holoprosencephaly, Familial Alobar

  • Hpe, Familial

  • Hpec

  • Demyer Sequence

  • Holoprosencephaly-1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS11476 PWP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PWP2 RGD RGD:1582817
Mus musculus PWP2 MGD MGI:1341200