OPRPN - opiorphin prepropeptide Gene

Also Known as BPLP; PRL1; PROL1; opiorphin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58503

About OPRPN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,397,940-70,410,195 (from NCBI)

This gene has 3 transcripts (splice variants) and 17 orthologues. Restricted expression toward salivary gland (RPKM 9.7).

Summary

This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases Neprilysin and Aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

OPRPN Products (2)

mRNA	Protein	Name
NM_001302807.2	NP_001289736.1	opiorphin prepropeptide isoform 2 precursor
NM_021225.5	NP_067048.4	opiorphin prepropeptide isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	17101991	GOA
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	17101991	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of sensory perception of pain	IDA IDA: Inferred from direct assay	17101991	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	17101991	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPRPN Protein Structure

PROL5-SMR

0
100
200
248 a.a.

Protein Preferred Names	Protein Names
opiorphin prepropeptide	basic proline-rich lacrimal protein

Related Diseases

Diseases	Alias
Penile Disease	Penile Diseases
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09807	OPRPN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OPRPN	VGNC	VGNC:75419
Rattus norvegicus	OPRPN	RGD	RGD:620983
Others	OPRPN	NCBI