Nr0b1 - nuclear receptor subfamily 0, group B, member 1 Gene

Also Known as Ahch; DAX-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58850

Summary

Enables double-stranded DNA binding activity and sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated; response to peptide hormone; and spermatogenesis. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr0b1 Products (1)

mRNA Protein Name
NM_053317.2 NP_445769.2 nuclear receptor subfamily 0 group B member 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables double-stranded DNA binding IMP
IMP: Inferred from mutant phenotype
12697699 RGD
enables sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
12697699 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12697699 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12697699 RGD
involved in response to benzoic acid IEP
IEP: Inferred from expression pattern
30476341 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15358680 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
30476341 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
8961266 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 0 group B member 1

  • adrenal hypoplasia, congenital homolog

  • nuclear receptor DAX-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122054 BPK-29 99.4% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 99.19% Unkown
HY-RS09525 NR0B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21003 Nr0b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27520 Nr0b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr0b1 NCBI NCBI:190