Fxyd1 - FXYD domain-containing ion transport regulator 1 Gene

Rattus norvegicus

Also known as Plm

Gene ID: 58971 | Gene type: protein coding

About Fxyd1

Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. [provided by RefSeq, Jul 2008]

Fxyd1 Products(1)

mRNA	Protein	Name
NM_031648.2	NP_113836.2	phospholemman precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	23532852	RGD
enables myosin binding	IDA IDA: Inferred from direct assay	23532852	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15774479	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of inorganic anion transmembrane transport	IMP IMP: Inferred from mutant phenotype	11336802	RGD
involved in positive regulation of organic acid transport	IMP IMP: Inferred from mutant phenotype	11336802	RGD
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	14684371	RGD
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	14684371	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	23532852	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12657675	RGD
located in caveola	IDA IDA: Inferred from direct assay	23532852	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	23532852	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15961612	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholemman

sodium/potassium-transporting ATPase subunit FXYD1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05165	FXYD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fxyd1	NCBI	NCBI:5348

Name
Email *

	Sorry, but the email address you supplied was invalid.