Slc30a1 - solute carrier family 30 member 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 58976

Summary

Enables Calcium Channel Inhibitor activity and zinc ion transmembrane transporter activity. Involved in detoxification of cadmium ion; metal ion transport; and negative regulation of neurotransmitter secretion. Acts upstream of or within zinc ion transport. Located in T-tubule. Is integral component of membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic density membrane. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc30a1 Products (1)

mRNA	Protein	Name
NM_022853.2	NP_074044.1	zinc transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium channel inhibitor activity	IMP IMP: Inferred from mutant phenotype	16741752	RGD
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	7882967	RGD
enables zinc ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	7882967	RGD
enables zinc:proton antiporter activity	IDA IDA: Inferred from direct assay	24951051	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cadmium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	16741752	RGD
involved in calcium ion import	IMP IMP: Inferred from mutant phenotype	16741752	RGD
involved in detoxification of cadmium ion	IMP IMP: Inferred from mutant phenotype	16741752	RGD
involved in negative regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	16741752	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	25319628	RGD
involved in regulation of postsynaptic density protein 95 clustering	IMP IMP: Inferred from mutant phenotype	25319628	RGD
involved in zinc export across plasma membrane	IDA IDA: Inferred from direct assay	24951051	RGD
involved in zinc export across plasma membrane	IMP IMP: Inferred from mutant phenotype	19095042	RGD
acts upstream of or within zinc ion transport	IDA IDA: Inferred from direct assay	7882967	RGD
involved in zinc ion transport	IDA IDA: Inferred from direct assay	7882967	RGD
involved in zinc ion transport	IMP IMP: Inferred from mutant phenotype	16741752	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	24602382	RGD
located in T-tubule	IDA IDA: Inferred from direct assay	16741752	RGD
located in dendrite	IDA IDA: Inferred from direct assay	25319628	RGD
located in glutamatergic postsynaptic density	IDA IDA: Inferred from direct assay	25319628	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	7882967	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	24602382	RGD
located in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	25319628	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc transporter 1	solute carrier family 30 (zinc transporter), member 1 znT-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13178	SLC30A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19095	Slc30a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25585	Slc30a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc30a1	NCBI	NCBI:7779