Slc4a8 - solute carrier family 4 (anion exchanger), member 8 Gene

Also Known as NDCBE; kNBC-3; C230026C11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59033

Summary

Predicted to enable chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Acts upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of intracellular pH. Located in several cellular components, including glutamatergic synapse; neuronal cell body membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a8 Products (2)

mRNA Protein Name
NM_001347102.1 NP_001334031.1 electroneutral sodium bicarbonate exchanger 1 isoform 2
NM_021530.2 NP_067505.2 electroneutral sodium bicarbonate exchanger 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sodium,bicarbonate:chloride antiporter activity IDA
IDA: Inferred from direct assay
20389022 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
23677982 MGI
acts upstream of or within modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
21593314 MGI
acts upstream of or within positive regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
21593314 MGI
acts upstream of or within regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
21593314 MGI
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
21593314 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
21593314 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
21593314 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
30355950 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
21593314 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21593314 MGI
located in glutamatergic synapse IDA
IDA: Inferred from direct assay
21593314 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
21593314 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21593314 MGI
located in membrane IDA
IDA: Inferred from direct assay
18359573 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
18359573 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
18359573 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18359573 MGI
located in presynapse IDA
IDA: Inferred from direct assay
21593314 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
21593314 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
21593314 MGI
is active in presynaptic membrane IEP
IEP: Inferred from expression pattern
21593314 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

electroneutral sodium bicarbonate exchanger 1

  • electroneutral Na+-driven Cl-HCO3 exchanger

  • k-NBC3

  • solute carrier family 4 member 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13273 SLC4A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21937 Slc4a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28453 Slc4a8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a8 NCBI NCBI:9498