Evc - EvC ciliary complex subunit 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59056

Summary

Involved in endochondral bone growth and positive regulation of smoothened signaling pathway. Located in ciliary basal body and ciliary membrane. Part of plasma membrane protein complex. Is expressed in aorta; heart; nose; skeleton; and vibrissa. Used to study Ellis-Van Creveld syndrome. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome and Weyers acrofacial dysostosis. Orthologous to human EVC (EvC ciliary complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Evc Products (1)

mRNA Protein Name
NM_021292.2 NP_067267.2 evC complex member EVC

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21356043 MGI
Biological Process GO Annotation Evidence References Source
involved in endochondral bone growth IMP
IMP: Inferred from mutant phenotype
17660199 MGI
involved in positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
17660199 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
17660199 MGI
located in ciliary membrane IDA
IDA: Inferred from direct assay
24582806 MGI
located in cilium IDA
IDA: Inferred from direct assay
21356043 MGI
part of plasma membrane protein complex IDA
IDA: Inferred from direct assay
24582806 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

evC complex member EVC

ellis-van Creveld syndrome protein homolog

  • Ellis van Creveld gene homolog

  • Ellis van Creveld gene syndrome

  • EvC protein (Ellis-van Creveld syndrome)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169322 APL-1081 Inhibitor 99.79% Unkown
HY-175888 APL-1082 95.58% Unkown
HY-169352 Mal-Exo-EVC / Unkown
HY-RS04572 EVC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04573 EVC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Evc NCBI NCBI:2121