Bhlhe22 - basic helix-loop-helix family, member e22 Gene

Also Known as Beta3; Beta3a; Bhlhb5

Species: Mus musculus

Gene Type: protein coding

Gene ID: 59058

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and identical protein binding activity. Acts upstream of or within cerebral cortex regionalization; negative regulation of transcription, DNA-templated; and neuron differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human BHLHE22 (basic helix-loop-helix family member e22). [provided by Alliance of Genome Resources, Apr 2022]

Bhlhe22 Products (1)

mRNA	Protein	Name
NM_021560.4	NP_067535.3	class E basic helix-loop-helix protein 22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22284184	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22284184	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22284184	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22284184	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within GABAergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17092954	MGI
acts upstream of or within amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	17092954	MGI
acts upstream of or within anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	22284184	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	22284184	MGI
acts upstream of or within cerebral cortex regionalization	IMP IMP: Inferred from mutant phenotype	23431145	MGI
acts upstream of or within corpus callosum morphogenesis	IMP IMP: Inferred from mutant phenotype	22284184	MGI
acts upstream of or within corticospinal tract morphogenesis	IGI IGI: Inferred from genetic interaction	22284184	MGI
acts upstream of or within corticospinal tract morphogenesis	IMP IMP: Inferred from mutant phenotype	22284184	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12213201	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	22284184	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	17092954	MGI
acts upstream of or within retinal bipolar neuron differentiation	IMP IMP: Inferred from mutant phenotype	17092954	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	22284184	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
class E basic helix-loop-helix protein 22	basic helix-loop-helix (bHLH) gene, class B, beta3 basic helix-loop-helix domain containing, class B5 class B basic helix-loop-helix protein 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01492	BHLHE22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bhlhe22	NCBI	NCBI:27319