Erbin - Erbb2 interacting protein Gene

Also Known as Erbb2ip; mKIAA1225; 1700028E05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59079

Summary

Predicted to enable signaling receptor binding activity. Involved in negative regulation of monocyte chemotactic protein-1 production; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within protein targeting. Located in basolateral plasma membrane and glutamatergic synapse. Is active in postsynapse. Is expressed in cerebral cortex and retina nuclear layer. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Erbin Products (4)

mRNA Protein Name
NM_001005868.2 NP_001005868.1 erbin isoform 1
NM_001289473.1 NP_001276402.1 erbin isoform 3
NM_001289474.1 NP_001276403.1 erbin isoform 4
NM_001289475.1 NP_001276404.1 erbin isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10878805 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
16203728 MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: Inferred from mutant phenotype
16203728 MGI
acts upstream of or within protein targeting IDA
IDA: Inferred from direct assay
10878805 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
23354328 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
23354328 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10878805 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23354328 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23354328 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
23354328 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

erbin

  • densin-180-like protein

  • erbb2-interacting protein

  • protein LAP2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04475 ERBIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbin NCBI NCBI:55914