ENPP5 - ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Gene

Also Known as NPP5; NPP-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59084

About ENPP5

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:46,159,185-46,170,980 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 6 paralogues. Biased expression in thyroid (RPKM 24.6), testis (RPKM 20.9) and 13 other tissues.

Summary

This gene encodes a type-I Transmembrane Glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]

ENPP5 Products (3)

mRNA Protein Name
NM_001290072.2 NP_001277001.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor
NM_001290073.2 NP_001277002.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 2
NM_021572.6 NP_067547.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables NAD+ diphosphatase activity IDA
IDA: Inferred from direct assay
28898552 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
28898552 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP5 Protein Structure

Phosphodiest

Phosphodiest: Type I phosphodiesterase / nucleotide pyrophosphatase (30 - 342)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

  • E-NPP 5

Recombinant ENPP5 Proteins

Cat. No. Product Name Accession Purity
HY-P75734 ENPP-5 Protein, Human (HEK293, His) Q9UJA9 (P25-G429) ≥ 95%, as determined by reducing SDS-PAGE.

ENPP5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86861 ENPP5 Antibody (YA6554) WB, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Ceroid Lipofuscinosis, Neuronal, 6a

  • Neuronal Ceroid Lipofuscinosis 6

  • CLN6

  • Vlincl

  • Cln6 Disease

  • Ceroid Lipofuscinosis, Neuronal, 6

  • Late-Infantile Neuronal Ceroid Lipofuscinosis

  • CLN6A

  • Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant

  • Neuronal Ceroid Lipofuscinosis 6a

  • Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset

  • Cln6 Disease, Adult Kufs Type A

  • Cln6 Disease, Late Infantile

  • Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant

  • Ceroid Lipofuscinosis Neuronal 6

  • Cln6-Related Neuronal Ceroid Lipofuscinosis

  • Late Infantile Neuronal Ceroid Lipofuscinosis

  • Jansky-Bielschowsky Disease

  • Lincl

  • Late Infantile Ncl

  • Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset

  • Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis

  • Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant

  • Lipofuscinosis, Ceroid, Neuronal, Type 6

  • Ceroid Lipofuscinosis, Neuronal, 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04391 ENPP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22487 Enpp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29010 Enpp5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ENPP5 RGD RGD:1359199
Macaca mulatta ENPP5 VGNC VGNC:104375
Canis familiaris ENPP5 VGNC VGNC:58978
Mus musculus ENPP5 MGD MGI:1933830
Felis catus ENPP5 VGNC VGNC:61875
Bos taurus ENPP5 VGNC VGNC:58979
Others ENPP5 NCBI