Ltbp1 - latent transforming growth factor beta binding protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59107

Summary

Predicted to enable microfibril binding activity and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ltbp1 Products (1)

mRNA Protein Name
NM_021587.2 NP_067598.2 latent-transforming growth factor beta-binding protein 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
9607192 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
15880704 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
14708940 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
10025676 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
9607192 RGD
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
9766531 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11720783 RGD
part of large latent transforming growth factor-beta complex IDA
IDA: Inferred from direct assay
11907708 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11720783 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9828223 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

latent-transforming growth factor beta-binding protein 1

  • LTBP-1

  • LanC (bacterial lantibiotic synthetase component C)-like 1

  • TGF-beta-1-BP-1

  • transforming growth factor beta-1-binding protein 1

  • transforming growth factor beta-1-masking protein large subunit

  • transforming growth factor-beta (TGF-beta) masking p

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07877 LTBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20052 Ltbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26556 Ltbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ltbp1 NCBI NCBI:4052