2. Gene
  3. RCN2 - reticulocalbin 2 Gene

RCN2 - reticulocalbin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as E6BP; ERC55; ERC-55; TCBP49

Gene ID: 5955 | Gene type: protein coding

About RCN2

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:76,931,749-76,954,393 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 51.1), brain (RPKM 32.7) and 24 other tissues.

Summary

The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

RCN2 Products(2)

mRNA Protein Name
NM_001271837.2 NP_001258766.1 reticulocalbin-2 isoform b precursor
NM_002902.3 NP_002893.1 reticulocalbin-2 isoform a precursor

RCN2 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (68 - 122)

EF-hand_5

EF-hand_5: EF hand (195 - 211)

EF-hand_7

EF-hand_7: EF-hand domain pair (237 - 289)

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  • 317 a.a.
Protein Preferred Names Protein Names

reticulocalbin-2

E6-binding protein

Recombinant RCN2 Proteins

Cat. No. Product Name Accession Purity
HY-P71252 RCN2 Protein, Human (HEK293, His) Q14257 (G23-L317) ≥95%

Related Diseases

Diseases Alias
Drug-Induced Lupus Erythematosus

Dile

Dil

Drug-Induced Systemic Lupus Erythematosus
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11789 RCN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RCN2 MGD MGI:1349765
Bos taurus RCN2 VGNC VGNC:33832
Rattus norvegicus RCN2 RGD RGD:3548
Felis catus RCN2 VGNC VGNC:69275
Macaca mulatta RCN2 VGNC VGNC:76887
Canis familiaris RCN2 VGNC VGNC:54349
Others RCN2 NCBI