RCN2 - reticulocalbin 2 Gene

Also Known as E6BP; ERC55; ERC-55; TCBP49

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5955

About RCN2

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:76,931,749-76,954,393 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 51.1), brain (RPKM 32.7) and 24 other tissues.

Summary

The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity CA(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

RCN2 Products (2)

mRNA Protein Name
NM_001271837.2 NP_001258766.1 reticulocalbin-2 isoform b precursor
NM_002902.3 NP_002893.1 reticulocalbin-2 isoform a precursor

RCN2 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (68 - 122)

EF-hand_5

EF-hand_5: EF hand (195 - 211)

EF-hand_7

EF-hand_7: EF-hand domain pair (237 - 289)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

reticulocalbin-2

  • E6-binding protein

RCN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
RCN2 Q14257 E6 Human papillomavirus P03126
Pull Down
7624774
Intra
RCN2 Q14257 UNG Homo sapiens P13051-2
Y2H Array
32814053
Intra
RCN2 Q14257 UNG Homo sapiens P13051-2
Validated Y2H
32814053
Intra
RCN2 Q14257 UNG Homo sapiens P13051-2
Y2H Pooling
32814053
Intra
RCN2 Q14257 STUB1 Homo sapiens Q9UNE7
Validated Y2H
32814053
Intra
RCN2 Q14257 STUB1 Homo sapiens Q9UNE7
Y2H Array
32814053
Intra
RCN2 Q14257 STUB1 Homo sapiens Q9UNE7
Y2H Pooling
32814053
Intra
RCN2 Q14257 GABARAPL2 Homo sapiens P60520
Y2H Prey Pooling
32296183
Intra
RCN2 Q14257 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RCN2 Proteins

Cat. No. Product Name Accession Purity
HY-P71252 RCN2/Reticulocalbin-2 Protein, Human (HEK293, His) Q14257 (G23-L317) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Drug-Induced Lupus Erythematosus

  • Dile

  • Dil

  • Drug-Induced Systemic Lupus Erythematosus
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11780 RCAN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11789 RCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19636 Rcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RCN2 MGD MGI:1349765
Bos taurus RCN2 VGNC VGNC:33832
Rattus norvegicus RCN2 RGD RGD:3548
Felis catus RCN2 VGNC VGNC:69275
Macaca mulatta RCN2 VGNC VGNC:76887
Canis familiaris RCN2 VGNC VGNC:54349
Others RCN2 NCBI