RLN2 - relaxin 2 Gene

Homo sapiens

Also known as H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2

Gene ID: 6019 | Gene type: protein coding

About RLN2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,299,864-5,339,326 (from NCBI)

This gene has 2 transcripts (splice variants), 90 orthologues and 3 paralogues. Biased expression in prostate (RPKM 1.9), testis (RPKM 0.8) and 12 other tissues.

Summary

This gene encodes a member of the relaxin subfamily and Insulin superfamily of peptide Hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]

RLN2 Products(3)

mRNA	Protein	Name
NM_001329191.2	NP_001316120.1	prorelaxin H2 isoform 3
NM_005059.4	NP_005050.2	prorelaxin H2 isoform 2 precursor
NM_134441.3	NP_604390.1	prorelaxin H2 isoform 1 preproprotein

RLN2 Protein Structure

Insulin

0
100
185 a.a.

Protein Preferred Names

Protein Names

prorelaxin H2

H2-preprorelaxin

Recombinant RLN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79134	RLN2/Relaxin-2 Protein, Human	P04090 (V23-R55) & P04090 (Q162-C185)	≥95%

Related Diseases

Diseases

Alias

Bone Squamous Cell Carcinoma

Spermatogenic Failure 8

SPGF8

Radiation Cystitis

Irradiation Cystitis

Auditory System Cancer

Ear Neoplasms

Otosalpingitis

Eustachian Salpingitis	Eustachian Tube Salpingitis
Rhinosalpingitis	Tubotympanitis
Eustachian Tube Inflammation	Salpingitis Of Ear

Peripartum Cardiomyopathy

Postpartum Cardiomyopathy	Peripartum Cardiomyopathy, Susceptibility To
Ppcm	Ppcm, Susceptibility To
Antepartum Peripartum Cardiomyopathy	Postpartum Peripartum Cardiomyopathy
Meadows' Syndrome	Cardiomyopathy, Peripartum

Bone Cancer

Malignant Bone Neoplasm	Bone Carcinoma
Bone Neoplasms	Bone Neoplasm
Bone Tumour	Ca - Bone Cancer
Malignant Bone Tumour	Malignant Neoplasm Of Bone
Malignant Osseous Tumor	Neoplasm Of Bone
Osseous Tumor	Osteosarcoma Of Bone
Osteogenic Neoplasm

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes	PPROM
Preterm Premature Rupture Of The Membranes, Susceptibility To	Pprom - [Preterm Premature Rupture Of Membranes]
Preterm Rupture Of Membranes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12010	RLN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RLN2	MGD	MGI:97931