RLN2 - relaxin 2 Gene

Also Known as H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6019

About RLN2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,299,864-5,339,326 (from NCBI)

This gene has 2 transcripts (splice variants), 90 orthologues and 3 paralogues. Biased expression in prostate (RPKM 1.9), testis (RPKM 0.8) and 12 other tissues.

Summary

This gene encodes a member of the relaxin subfamily and Insulin superfamily of peptide Hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]

RLN2 Products (3)

mRNA	Protein	Name
NM_001329191.2	NP_001316120.1	prorelaxin H2 isoform 3
NM_005059.4	NP_005050.2	prorelaxin H2 isoform 2 precursor
NM_134441.3	NP_604390.1	prorelaxin H2 isoform 1 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16049981	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	11459784	GOA
involved in regulation of catalytic activity	IDA IDA: Inferred from direct assay	16049981	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RLN2 Protein Structure

Insulin

0
100
185 a.a.

Protein Preferred Names	Protein Names
prorelaxin H2	H2-preprorelaxin

Related Diseases

Diseases	Alias
Bone Squamous Cell Carcinoma
Spermatogenic Failure 8	SPGF8
Radiation Cystitis	Irradiation Cystitis
Auditory System Cancer	Ear Neoplasms
Otosalpingitis	Eustachian Salpingitis Eustachian Tube Salpingitis Rhinosalpingitis Tubotympanitis Eustachian Tube Inflammation Salpingitis Of Ear
Peripartum Cardiomyopathy	Postpartum Cardiomyopathy Peripartum Cardiomyopathy, Susceptibility To Ppcm Ppcm, Susceptibility To Antepartum Peripartum Cardiomyopathy Postpartum Peripartum Cardiomyopathy Meadows' Syndrome Cardiomyopathy, Peripartum
Bone Cancer	Malignant Bone Neoplasm Bone Carcinoma Bone Neoplasms Bone Neoplasm Bone Tumour Ca - Bone Cancer Malignant Bone Tumour Malignant Neoplasm Of Bone Malignant Osseous Tumor Neoplasm Of Bone Osseous Tumor Osteosarcoma Of Bone Osteogenic Neoplasm
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12010	RLN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RLN2	MGD	MGI:97931
Others	RLN2	NCBI