NRXN1 - Nrxn1 neurexin 1 Gene

Also Known as Nrxn1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60391

Summary

This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. [provided by RefSeq, Nov 2016]

NRXN1 Products (1)

mRNA Protein Name
NM_021767.3 NP_068535.3 neurexin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
18334216 RGD
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
15152050 RGD
enables neuroligin family protein binding IPI
IPI: Inferred from physical interaction
14522992 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18093521 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18093522 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15797875 RGD
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
15797875 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
14522992 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
22662246 RGD
involved in presynapse assembly EXP
EXP: Inferred from Experiment
12796785 RGD
involved in presynapse assembly IDA
IDA: Inferred from direct assay
12796785 RGD
involved in presynapse assembly IMP
IMP: Inferred from mutant phenotype
12796785 RGD
involved in signal transduction IDA
IDA: Inferred from direct assay
15797875 RGD
acts upstream of or within vesicle docking involved in exocytosis IMP
IMP: Inferred from mutant phenotype
22235116 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15797875 RGD
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15797875 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
22235116 RGD
located in slit diaphragm IDA
IDA: Inferred from direct assay
21048075 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurexin-1

  • 60S ribosomal protein L10a pseudogene

  • neurexin I-alpha

  • neurexin I-beta

  • neurexin-1-alpha

  • neurexin-1-beta

  • non-processed neurexin I-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09583 NRXN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21669 Nrxn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28187 Nrxn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NRXN1 NCBI NCBI:9378