Slc18a3 - solute carrier family 18 member A3 Gene

Rattus norvegicus

Also known as rVAT; VACht

Gene ID: 60422 | Gene type: protein coding

About Slc18a3

Summary

Enables acetylcholine transmembrane transporter activity. Involved in acetylcholine transport and neurotransmitter loading into synaptic vesicle. Located in axon terminus and synaptic vesicle. Part of AP-1 adaptor complex and AP-2 adaptor complex. Is active in cholinergic synapse and neuromuscular junction. Is integral component of synaptic vesicle membrane. Biomarker of asthma and bladder disease. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a3 Products(1)

mRNA	Protein	Name
NM_031663.2	NP_113851.1	vesicular acetylcholine transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine transmembrane transporter activity	IDA IDA: Inferred from direct assay	8071310	RGD
enables acetylcholine:proton antiporter activity	IDA IDA: Inferred from direct assay	8071310	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine transport	IMP IMP: Inferred from mutant phenotype	15924414	RGD
involved in acetylcholine uptake	IDA IDA: Inferred from direct assay	8071310	RGD
involved in neurotransmitter loading into synaptic vesicle	IDA IDA: Inferred from direct assay	9182805	RGD
involved in neurotransmitter loading into synaptic vesicle	IMP IMP: Inferred from mutant phenotype	9182805	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AP-1 adaptor complex	IDA IDA: Inferred from direct assay	14724281	RGD
part of AP-2 adaptor complex	IDA IDA: Inferred from direct assay	14724281	RGD
located in axon	IDA IDA: Inferred from direct assay	19374941	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	15306235	RGD
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	8601799	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	8622973	RGD
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	9182805	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15306235	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	8601799	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	9182805	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicular acetylcholine transporter

solute carrier family 18 (vesicular acetylcholine transporter), member 3	solute carrier family 18 (vesicular acetylcholine), member 3
solute carrier family 18 (vesicular monoamine) member 3	solute carrier family 18, member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13045	SLC18A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22033	Slc18a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc18a3	NCBI	NCBI:6572

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