Slc18a3 - solute carrier family 18 member A3 Gene

Also Known as rVAT; VACht

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60422

Summary

Enables acetylcholine transmembrane transporter activity. Involved in acetylcholine transport and neurotransmitter loading into synaptic vesicle. Located in axon terminus and synaptic vesicle. Part of AP-1 adaptor complex and AP-2 adaptor complex. Is active in cholinergic synapse and neuromuscular junction. Is integral component of synaptic vesicle membrane. Biomarker of asthma and bladder disease. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a3 Products (1)

mRNA Protein Name
NM_031663.2 NP_113851.1 vesicular acetylcholine transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine transmembrane transporter activity IDA
IDA: Inferred from direct assay
8071310 RGD
enables acetylcholine:proton antiporter activity IDA
IDA: Inferred from direct assay
8071310 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine transport IMP
IMP: Inferred from mutant phenotype
15924414 RGD
involved in acetylcholine uptake IDA
IDA: Inferred from direct assay
8071310 RGD
involved in neurotransmitter loading into synaptic vesicle IDA
IDA: Inferred from direct assay
9182805 RGD
involved in neurotransmitter loading into synaptic vesicle IMP
IMP: Inferred from mutant phenotype
9182805 RGD
Cellular Component GO Annotation Evidence References Source
part of AP-1 adaptor complex IDA
IDA: Inferred from direct assay
14724281 RGD
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
14724281 RGD
located in axon IDA
IDA: Inferred from direct assay
19374941 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
15306235 RGD
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
8601799 RGD
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
8622973 RGD
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
9182805 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
15306235 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
8601799 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
9182805 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicular acetylcholine transporter

  • solute carrier family 18 (vesicular acetylcholine transporter), member 3

  • solute carrier family 18 (vesicular acetylcholine), member 3

  • solute carrier family 18 (vesicular monoamine) member 3

  • solute carrier family 18, member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13045 SLC18A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22033 Slc18a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc18a3 NCBI NCBI:6572