TGIF2 - TGFB induced factor homeobox 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60436

About TGIF2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,573,464-36,593,950 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 12 paralogues. Ubiquitous expression in endometrium (RPKM 10.3), lymph node (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]

TGIF2 Products (4)

mRNA Protein Name
NM_001199513.2 NP_001186442.1 homeobox protein TGIF2
NM_001199514.2 NP_001186443.1 homeobox protein TGIF2
NM_001199515.2 NP_001186444.1 homeobox protein TGIF2
NM_021809.7 NP_068581.1 homeobox protein TGIF2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22783022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGIF2 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (36 - 75)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

homeobox protein TGIF2

  • 5'-TG-3' interacting factor 2

Related Diseases

Diseases Alias
Holoprosencephaly 4

  • HPE4

  • Holoprosencephaly-4

  • Holoprosencephaly, Type 4
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14456 TGIF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14457 TGIF2LX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TGIF2 VGNC VGNC:35808
Mus musculus TGIF2 MGD MGI:1915299
Rattus norvegicus TGIF2 RGD RGD:1560115
Felis catus TGIF2 VGNC VGNC:66140
Canis familiaris TGIF2 VGNC VGNC:47314
Others TGIF2 NCBI