Trp53inp1 - transformation related protein 53 inducible nuclear protein 1 Gene

Mus musculus

Also known as SIP; Teap; SIP18; SIP27; Stinp; Tp53inp1; p53DINP1; 2700057G22Rik

Gene ID: 60599 | Gene type: protein coding

About Trp53inp1

Summary

Enables antioxidant activity. Involved in several processes, including negative regulation of fibroblast proliferation; negative regulation of myofibroblast differentiation; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to ethanol; cellular response to hydroperoxide; and cellular response to methyl methanesulfonate. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study abdominal obesity-metabolic syndrome 1. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Trp53inp1 Products(2)

mRNA	Protein	Name
NM_001199105.2	NP_001186034.1	tumor protein p53-inducible nuclear protein 1 isoform 2
NM_021897.4	NP_068697.1	tumor protein p53-inducible nuclear protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antioxidant activity	IMP IMP: Inferred from mutant phenotype	19118006	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to UV	IDA IDA: Inferred from direct assay	11557757	MGI
acts upstream of or within cellular response to ethanol	IDA IDA: Inferred from direct assay	11557757	MGI
acts upstream of or within cellular response to hydroperoxide	IDA IDA: Inferred from direct assay	11557757	MGI
acts upstream of or within cellular response to methyl methanesulfonate	IDA IDA: Inferred from direct assay	11557757	MGI
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21339733	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19118006	MGI
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	26589288	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26589288	MGI
involved in negative regulation of myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	26589288	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	11557757	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26589288	MGI
acts upstream of or within response to heat	IDA IDA: Inferred from direct assay	11557757	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
NOT located in nucleolus	IDA IDA: Inferred from direct assay	11557757	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11557757	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor protein p53-inducible nuclear protein 1

p53-dependent damage-inducible nuclear protein 1	stress induced protein
thymus-expressed acidic protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS28596	Tp53inp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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