DHX35 - DEAH-box helicase 35 Gene
Also Known as DDX35; C20orf15; KAIA0875
生物種: Homo sapiens
About DHX35
This gene has 8 transcripts (splice variants), 200 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 6.1), endometrium (RPKM 6.0) and 25 other tissues.
Summary
DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]
DHX35 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001190809.2 | NP_001177738.1 | probable ATP-dependent RNA helicase DHX35 isoform 2 |
| NM_021931.4 | NP_068750.2 | probable ATP-dependent RNA helicase DHX35 isoform 1 |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of catalytic step 2 spliceosome |
IDA
IDA: Inferred from direct assay
|
11991638 | GOA |
DHX35 Protein Structure
Helicase_C: Helicase conserved C-terminal domain (307 - 397)
HA2: Helicase associated domain (HA2) (458 - 549)
OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (584 - 684)
- 0
- 200
- 400
- 600
- 703 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
probable ATP-dependent RNA helicase DHX35 |
|
関連疾患
| Diseases | Alias | |
|---|---|---|
| Cranioectodermal Dysplasia 2 |
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Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Canis familiaris | DHX35 | VGNC | VGNC:39945 |
| Rattus norvegicus | DHX35 | RGD | RGD:1311165 |
| Mus musculus | DHX35 | MGD | MGI:1918965 |
| Felis catus | DHX35 | VGNC | VGNC:61480 |
| Bos taurus | DHX35 | VGNC | VGNC:28053 |
| Others | DHX35 | NCBI |