Ppp2r2b - protein phosphatase 2, regulatory subunit B, beta Gene

Also Known as Pppr2b2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60660

Summary

Predicted to enable protein Phosphatase regulator activity. Involved in several processes, including mitochondrion organization; nervous system development; and positive regulation of neuron apoptotic process. Located in cytosol and mitochondrial outer membrane. Part of protein Phosphatase type 2A complex. Colocalizes with Cytoskeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein Phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2r2b Products (2)

mRNA Protein Name
NM_001402382.1 NP_001389311.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 2
NM_022209.4 NP_071545.2 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15923182 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
12716901 RGD
Biological Process GO Annotation Evidence References Source
involved in mitochondrial fission IDA
IDA: Inferred from direct assay
18940801 RGD
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
18940801 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
12716901 RGD
involved in positive regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
12716901 RGD
involved in protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
12716901 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
8389301 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12716901 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
15923182 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
12716901 RGD
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
12716901 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

  • BRbeta B-regulatory subunit of protein phosphatase 2A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11012 PPP2R2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp2r2b NCBI NCBI:5521