Ppp2r2b - protein phosphatase 2, regulatory subunit B, beta Gene

Rattus norvegicus

Also known as Pppr2b2

Gene ID: 60660 | Gene type: protein coding

About Ppp2r2b

Summary

Predicted to enable protein Phosphatase regulator activity. Involved in several processes, including mitochondrion organization; nervous system development; and positive regulation of neuron apoptotic process. Located in cytosol and mitochondrial outer membrane. Part of protein Phosphatase type 2A complex. Colocalizes with Cytoskeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein Phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2r2b Products(2)

mRNA	Protein	Name
NM_001402382.1	NP_001389311.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 2
NM_022209.4	NP_071545.2	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15923182	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12716901	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial fission	IDA IDA: Inferred from direct assay	18940801	RGD
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18940801	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	12716901	RGD
involved in positive regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	12716901	RGD
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	12716901	RGD
involved in spermatid development	IEP IEP: Inferred from expression pattern	8389301	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12716901	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15923182	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	12716901	RGD
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	12716901	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

BRbeta B-regulatory subunit of protein phosphatase 2A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11012	PPP2R2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp2r2b	NCBI	NCBI:5521

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