CELF6 - CUGBP Elav-like family member 6 Gene

Also Known as BRUNOL6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60677

About CELF6

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,284,727-72,320,157 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 5.2), ovary (RPKM 3.9) and 24 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

CELF6 Products (3)

mRNA Protein Name
NM_001172684.2 NP_001166155.1 CUGBP Elav-like family member 6 isoform 2
NM_001172685.2 NP_001166156.1 CUGBP Elav-like family member 6 isoform 3
NM_052840.5 NP_443072.3 CUGBP Elav-like family member 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
14761971 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELF6 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (48 - 115)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (136 - 198)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (398 - 467)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

CUGBP Elav-like family member 6

  • Bruno -like 6, RNA binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02464 CELF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CELF6 MGD MGI:1923433
Rattus norvegicus CELF6 RGD RGD:1310451