HCN2 - hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Gene

Also Known as FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 610

About HCN2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:589,881-617,159 (from NCBI)

This gene has 1 transcript (splice variant), 256 orthologues, 17 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues.

Summary

The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]

HCN2 Products (1)

mRNA Protein Name
NM_001194.4 NP_001185.3 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

HCN2 Protein Structure

Ion_trans_N

Ion_trans_N: Ion transport protein N-terminal (166 - 241)

Ion_trans

Ion_trans: Ion transport protein (246 - 460)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (563 - 646)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 889 a.a.
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

  • brain cyclic nucleotide-gated channel 2

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized 17

  • Febrile Seizures, Familial, 2

  • EIG17

  • Familial Febrile Seizures 2

  • FEB2

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 17

  • Familial Febrile Convulsions 2

  • Convulsions, Familial Febrile, 2
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Epilepsy, Idiopathic Generalized

  • Idiopathic Generalized Epilepsy

  • Generalised Epilepsy

  • Epilepsy, Generalized

  • EIG

  • Ige

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 1

  • Epilepsy, Idiopathic Generalized 1

  • Epilepsy, Idiopathic Generalized, Susceptibility To

  • Epilepsy, Idiopathic, Generalized

  • Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Retinitis Pigmentosa 25

  • RP25

  • Retinitis Pigmentosa-25

  • Retinitis Pigmentosa, Type 25
Childhood Absence Epilepsy

  • Pyknolepsy

  • Petit Mal Epilepsy

  • Absence Seizures

  • Absence Seizure

  • Petit Mal Seizure

  • Absence Epilepsy, Childhood

  • Pykno-Epilepsy

  • Epilepsy, Absence

  • Absence Epilepsy

  • Pycnolepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160505 RO-275 Inhibitor 99.95% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-186056 HCN2-IN-3 Inhibitor / Unkown
HY-186057 HCN2-IN-5 Inhibitor / Unkown
HY-186058 HCN2-IN-6 Inhibitor / Unkown
HY-186059 HCN2 modulator-4 Inhibitor / Unkown
HY-186059A HCN2 modulator-5 Inhibitor / Unkown
HY-186060 HCN2 modulator-6 Inhibitor / Unkown
HY-186061 HCN2-IN-4 Inhibitor / Unkown
HY-186061A HCN2 modulator-8 Inhibitor / Unkown
HY-186062 HCN-IN-1 / Unkown
HY-186065 HCN2-IN-1 Inhibitor / Unkown
HY-186066 HCN2-IN-2 Inhibitor / Unkown
HY-RS06047 HCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18617 Hcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25103 Hcn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HCN2 VGNC VGNC:29777
Felis catus HCN2 VGNC VGNC:102610
Rattus norvegicus HCN2 RGD RGD:620689
Canis familiaris HCN2 VGNC VGNC:81268
Mus musculus HCN2 MGD MGI:1298210
Others HCN2 NCBI