2. Gene
  3. HCN2 - hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Gene

HCN2 - hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11

Gene ID: 610 | Gene type: protein coding

About HCN2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:589,881-617,159 (from NCBI)

This gene has 1 transcript (splice variant), 256 orthologues, 17 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues.

Summary

The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]

HCN2 Products(1)

mRNA Protein Name
NM_001194.4 NP_001185.3 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

HCN2 Protein Structure

Ion_trans_N

Ion_trans_N: Ion transport protein N-terminal (166 - 241)

Ion_trans

Ion_trans: Ion transport protein (246 - 460)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (563 - 646)

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  • 889 a.a.
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

brain cyclic nucleotide-gated channel 2

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized 17

Febrile Seizures, Familial, 2

EIG17

Familial Febrile Seizures 2

FEB2

Epilepsy, Idiopathic Generalized, Susceptibility To, 17

Familial Febrile Convulsions 2

Convulsions, Familial Febrile, 2
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy

Generalised Epilepsy

Epilepsy, Generalized

EIG

Ige

Epilepsy, Idiopathic Generalized, Susceptibility To, 1

Epilepsy, Idiopathic Generalized 1

Epilepsy, Idiopathic Generalized, Susceptibility To

Epilepsy, Idiopathic, Generalized

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Retinitis Pigmentosa 25

RP25

Retinitis Pigmentosa-25

Retinitis Pigmentosa, Type 25
Childhood Absence Epilepsy

Pyknolepsy

Petit Mal Epilepsy

Absence Seizures

Absence Seizure

Petit Mal Seizure

Absence Epilepsy, Childhood

Pykno-Epilepsy

Epilepsy, Absence

Absence Epilepsy

Pycnolepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13422 Zatebradine hydrochloride Antagonist 99.06% Unkown
HY-13422A Zatebradine Antagonist 99.59% Unkown
HY-RS06047 HCN2 Human Pre-designed siRNA Set A / Unkown
HY-160505 RO-275 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HCN2 VGNC VGNC:29777
Felis catus HCN2 VGNC VGNC:102610
Rattus norvegicus HCN2 RGD RGD:620689
Canis familiaris HCN2 VGNC VGNC:81268
Mus musculus HCN2 MGD MGI:1298210