2. Membrane Transporter/Ion Channel
  3. HCN Channel
  4. RO-275

RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder.

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RO-275 Chemical Structure

RO-275 Chemical Structure

CAS No. : 2648837-04-9

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RO-275 Related Antibodies

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Description

RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder[1][2].

IC50 & Target

IC50: 0.046 µM (HCN1); 14.3 µM (HCN2); 4.6 µM (HCN3); 13.9 µM (HCN4)[1]
In Vivo

RO-275 (3, 10, 30 mg/kg; i.p.) rescues decremented working memory in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[2]
Dosage: 3, 10, 30 mg/kg
Administration: I.p.
Result: Improved performance in a translationally relevant touchscreen task of working memory (WM), tended to improve performance, but only at the longest delay of 6 s at the 10 mg/kg dose level, and led to a significant reduction in incorrect trials at 30 mg/kg in trial-unique, delayed non-matching-to-location (TUNL).
Molecular Weight

351.79

Formula

C18H14ClN5O
CAS No.
SMILES

O=C(C1=NC(C#CC2=C(C)C(Cl)=NC=C2)=C(C)N1C3=CC=CN=C3)N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RO-275 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO-2752648837-04-9RO275RO 275HCN ChannelHyperpolarization activated cyclic nucleotide gated channelssynapticworking memorybrain disorderInhibitorinhibitorinhibit

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