2648837-04-9
2648837-04-9
Chemical Structure
RO-275
- CAS 番号: 2648837-04-9
- Formula:C18H14ClN5O
- Molecular Weight:351.79
InChIKey: STQKUEFQEVDNLU-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C#CC2=C(C)C(Cl)=NC=C2)=C(C)N1C3=CC=CN=C3)N
Biological Activity: RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder[1][2].
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RO-275 | 99.95% | RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder. | ||||||||||||||||||||
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References
- [1]. Bjoern Bartels, et al. Alkynyl-(heteroaryl)-carboxamide hcn1 inhibitors. WO2021110574A1.
- [2]. Harde E, et al. Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell Chem Biol. 2024 Mar 21;31(3):577-592.e23. [Content Brief]
Keywords
