Kcnq1ot1 - KCNQ1 overlapping transcript 1 Gene

Also Known as Lit1; Tssc8; Kvlqt1-as

Species: Mus musculus

Gene Type: ncRNA
Gene ID: 63830

Summary

The distal end of mouse chromosome 7 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The telomeric imprinted domain is regulated by an ICR located in an intron of Kcnq1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the Kcnq1ot1 gene that is exclusively expressed from the paternal allele. The Kcnq1ot1 transcript is the antisense to the Kcnq1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. [provided by RefSeq, Mar 2012]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables chromatin binding IDA
IDA: Inferred from direct assay
20573698 MGI
enables miRNA binding IDA
IDA: Inferred from direct assay
32060985 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20573698 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
21172659 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in apoptotic process involved in development IMP
IMP: Inferred from mutant phenotype
32060985 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
32060985 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
32060985 MGI
acts upstream of or within genomic imprinting IDA
IDA: Inferred from direct assay
15340049 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
20573698 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: Inferred from direct assay
15340049 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: Inferred from mutant phenotype
20573698 MGI
involved in osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
32060985 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq1ot1 NCBI NCBI:10984