Kcnq1ot1 - KCNQ1 overlapping transcript 1 Gene

Mus musculus

Also known as Lit1; Tssc8; Kvlqt1-as

Gene ID: 63830 | Gene type: ncRNA

About Kcnq1ot1

Summary

The distal end of mouse chromosome 7 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The telomeric imprinted domain is regulated by an ICR located in an intron of Kcnq1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the Kcnq1ot1 gene that is exclusively expressed from the paternal allele. The Kcnq1ot1 transcript is the antisense to the Kcnq1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. [provided by RefSeq, Mar 2012]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20573698	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	32060985	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20573698	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	21172659	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process involved in development	IMP IMP: Inferred from mutant phenotype	32060985	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	32060985	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	32060985	MGI
acts upstream of or within genomic imprinting	IDA IDA: Inferred from direct assay	15340049	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	20573698	MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation	IDA IDA: Inferred from direct assay	15340049	MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	20573698	MGI
involved in osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	32060985	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnq1ot1	NCBI	NCBI:10984

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