Bco1 - beta-carotene oxygenase 1 Gene

Also Known as Bcdo; CMO1; Cmoi; Bcdo1; Bcmo1; beta-CD; betaCMOOX

Species: Mus musculus

Gene Type: protein coding
Gene ID: 63857

Summary

Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. Two alternatively spliced variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Bco1 Products (2)

mRNA Protein Name
NM_001163028.2 NP_001156500.1 beta,beta-carotene 15,15'-dioxygenase isoform 2
NM_021486.4 NP_067461.2 beta,beta-carotene 15,15'-dioxygenase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-carotene 15,15'-dioxygenase activity IDA
IDA: Inferred from direct assay
11092891 MGI
enables beta-carotene 15,15'-dioxygenase activity IMP
IMP: Inferred from mutant phenotype
15951442 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within beta-carotene metabolic process IMP
IMP: Inferred from mutant phenotype
25701869 MGI
involved in carotene catabolic process IDA
IDA: Inferred from direct assay
11092891 MGI
involved in carotene catabolic process IMP
IMP: Inferred from mutant phenotype
15951442 MGI
acts upstream of or within retinal metabolic process IGI
IGI: Inferred from genetic interaction
25701869 MGI
involved in retinal metabolic process IMP
IMP: Inferred from mutant phenotype
15951442 MGI
involved in retinoid metabolic process IDA
IDA: Inferred from direct assay
11092891 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta,beta-carotene 15,15'-dioxygenase

  • beta,beta-carotene 15,15'-monooxygenase

  • beta-carotene 15, 15'-dioxygenase 1

  • beta-carotene 15,15' dioxygenase

  • beta-carotene 15,15'-monooxygenase

  • beta-carotene cleavage enzyme

  • beta-carotene dioxygenase 1

  • carotenoid-15,15'-oxygenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01446 BCO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bco1 NCBI NCBI:53630