2. Gene
  3. Bco1 - beta-carotene oxygenase 1 Gene

Bco1 - beta-carotene oxygenase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bcdo; CMO1; Cmoi; Bcdo1; Bcmo1; beta-CD; betaCMOOX

Gene ID: 63857 | Gene type: protein coding

About Bco1

Summary

Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. Two alternatively spliced variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Bco1 Products(2)

mRNA Protein Name
NM_001163028.2 NP_001156500.1 beta,beta-carotene 15,15'-dioxygenase isoform 2
NM_021486.4 NP_067461.2 beta,beta-carotene 15,15'-dioxygenase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables beta-carotene 15,15'-dioxygenase activity IDA
IDA: Inferred from direct assay
11092891 MGI
enables beta-carotene 15,15'-dioxygenase activity IMP
IMP: Inferred from mutant phenotype
15951442 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within beta-carotene metabolic process IMP
IMP: Inferred from mutant phenotype
25701869 MGI
involved in carotene catabolic process IDA
IDA: Inferred from direct assay
11092891 MGI
involved in carotene catabolic process IMP
IMP: Inferred from mutant phenotype
15951442 MGI
acts upstream of or within retinal metabolic process IGI
IGI: Inferred from genetic interaction
25701869 MGI
involved in retinal metabolic process IMP
IMP: Inferred from mutant phenotype
15951442 MGI
involved in retinoid metabolic process IDA
IDA: Inferred from direct assay
11092891 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta,beta-carotene 15,15'-dioxygenase

beta,beta-carotene 15,15'-monooxygenase

beta-carotene 15, 15'-dioxygenase 1

beta-carotene 15,15' dioxygenase

beta-carotene 15,15'-monooxygenase

beta-carotene cleavage enzyme

beta-carotene dioxygenase 1

carotenoid-15,15'-oxygenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01446 BCO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bco1 NCBI NCBI:53630