2. Gene
  3. Hsd17b10 - hydroxysteroid (17-beta) dehydrogenase 10 Gene

Hsd17b10 - hydroxysteroid (17-beta) dehydrogenase 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ABAD; ERAB; MHBD; HSD10; Hadh2

Gene ID: 63864 | Gene type: protein coding

About Hsd17b10

Summary

Enables several functions, including amyloid-beta binding activity; Estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Leydig cell differentiation and cell aging. Located in mitochondrion. Human ortholog(s) of this gene implicated in chromosome Xp11.22 duplication syndrome; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b10 Products(1)

mRNA Protein Name
NM_031682.2 NP_113870.1 3-hydroxyacyl-CoA dehydrogenase type-2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables NAD binding IDA
IDA: Inferred from direct assay
11023795 RGD
enables acetoacetyl-CoA reductase activity IDA
IDA: Inferred from direct assay
11023795 RGD
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
11023795 RGD
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
11023795 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11023795 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19422801 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
11023795 RGD
Biological Process GO Annotation Evidence Reference Source
involved in Leydig cell differentiation IEP
IEP: Inferred from expression pattern
12810569 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12810569 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-hydroxyacyl-CoA dehydrogenase type-2

17-beta-HSD 10

17-beta-estradiol 17-dehydrogenase

17-beta-hydroxysteroid dehydrogenase 10

17I(2)-hydroxysteroid dehydrogenase type 10

2-methyl-3-hydroxybutyryl-CoA dehydrogenase

3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))

3-hydroxy-2-met

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06390 HSD17B10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b10 NCBI NCBI:3028