Hsd17b10 - hydroxysteroid (17-beta) dehydrogenase 10 Gene

Also Known as ABAD; ERAB; MHBD; HSD10; Hadh2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63864

Summary

Enables several functions, including amyloid-beta binding activity; Estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Leydig cell differentiation and cell aging. Located in mitochondrion. Human ortholog(s) of this gene implicated in chromosome Xp11.22 duplication syndrome; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b10 Products (1)

mRNA Protein Name
NM_031682.2 NP_113870.1 3-hydroxyacyl-CoA dehydrogenase type-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD binding IDA
IDA: Inferred from direct assay
11023795 RGD
enables acetoacetyl-CoA reductase activity IDA
IDA: Inferred from direct assay
11023795 RGD
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
11023795 RGD
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
11023795 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11023795 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19422801 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
11023795 RGD
Biological Process GO Annotation Evidence References Source
involved in Leydig cell differentiation IEP
IEP: Inferred from expression pattern
12810569 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12810569 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-hydroxyacyl-CoA dehydrogenase type-2

  • 17-beta-HSD 10

  • 17-beta-estradiol 17-dehydrogenase

  • 17-beta-hydroxysteroid dehydrogenase 10

  • 17I(2)-hydroxysteroid dehydrogenase type 10

  • 2-methyl-3-hydroxybutyryl-CoA dehydrogenase

  • 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))

  • 3-hydroxy-2-met

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06390 HSD17B10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b10 NCBI NCBI:3028