2. Gene
  3. Rapgef1 - Rap guanine nucleotide exchange factor 1 Gene

Rapgef1 - Rap guanine nucleotide exchange factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as C3g; Grf2; C3G-1; C3G-2

Gene ID: 63881 | Gene type: protein coding

About Rapgef1

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of Fc-gamma Receptor signaling pathway involved in phagocytosis; positive regulation of neuron projection development; and regulation of MAPK cascade. Located in perinuclear region of cytoplasm and phagocytic vesicle membrane. Part of protein-containing complex. Biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef1 Products(20)

mRNA Protein Name
XM_039106166.1 XP_038962094.1 rap guanine nucleotide exchange factor 1 isoform X15
XM_039106160.1 XP_038962088.1 rap guanine nucleotide exchange factor 1 isoform X5
XM_039106164.1 XP_038962092.1 rap guanine nucleotide exchange factor 1 isoform X11
XM_039106157.1 XP_038962085.1 rap guanine nucleotide exchange factor 1 isoform X1
XM_039106163.1 XP_038962091.1 rap guanine nucleotide exchange factor 1 isoform X9
XM_039106158.1 XP_038962086.1 rap guanine nucleotide exchange factor 1 isoform X2
XM_039106162.1 XP_038962090.1 rap guanine nucleotide exchange factor 1 isoform X8
XM_039106165.1 XP_038962093.1 rap guanine nucleotide exchange factor 1 isoform X12
XM_039106159.1 XP_038962087.1 rap guanine nucleotide exchange factor 1 isoform X4
XM_017592102.2 XP_017447591.1 rap guanine nucleotide exchange factor 1 isoform X3
XM_039106167.1 XP_038962095.1 rap guanine nucleotide exchange factor 1 isoform X16
XM_008761683.3 XP_008759905.2 rap guanine nucleotide exchange factor 1 isoform X6
XM_039106161.1 XP_038962089.1 rap guanine nucleotide exchange factor 1 isoform X7
XM_008761685.3 XP_008759907.2 rap guanine nucleotide exchange factor 1 isoform X13
XM_039106168.1 XP_038962096.1 rap guanine nucleotide exchange factor 1 isoform X18
XM_008761684.3 XP_008759906.2 rap guanine nucleotide exchange factor 1 isoform X10
XM_008761686.3 XP_008759908.2 rap guanine nucleotide exchange factor 1 isoform X14
XM_017592108.2 XP_017447597.1 rap guanine nucleotide exchange factor 1 isoform X17
XM_006233902.4 XP_006233964.1 rap guanine nucleotide exchange factor 1 isoform X19
XM_039106169.1 XP_038962097.1 rap guanine nucleotide exchange factor 1 isoform X20
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20190816 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
16507992 RGD
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: Inferred from mutant phenotype
18832707 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20190816 RGD
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
18832707 RGD
involved in regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
10811109 RGD
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18832707 RGD
located in phagocytic vesicle membrane IDA
IDA: Inferred from direct assay
18832707 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20190816 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Rap guanine nucleotide exchange factor 1

rap guanine nucleotide exchange factor 1

Rap guanine nucleotide exchange factor (GEF) 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11660 RAPGEF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rapgef1 NCBI NCBI:2889