TNN - tenascin N Gene

Also Known as TNW; TN-W

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63923

About TNN

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:175,067,833-175,148,075 (from NCBI)

This gene has 2 transcripts (splice variants), 126 orthologues and 25 paralogues. Biased expression in fat (RPKM 11.1), thyroid (RPKM 1.5) and 2 other tissues.

Summary

Predicted to enable Integrin binding activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; and negative regulation of osteoblast differentiation. Predicted to act upstream of or within axonogenesis. Predicted to be located in extracellular matrix and neuron projection. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TNN Products (1)

mRNA Protein Name
NM_022093.2 NP_071376.1 tenascin-N precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of sprouting angiogenesis IDA
IDA: Inferred from direct assay
19884327 GOA
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
17909022 GOA
involved in regulation of cell migration IDA
IDA: Inferred from direct assay
17909022 GOA
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
19884327 GOA
part of tenascin complex IPI
IPI: Inferred from physical interaction
17909022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNN Protein Structure

fn3

fn3: Fibronectin type III domain (265 - 337)

fn3

fn3: Fibronectin type III domain (359 - 430)

fn3

fn3: Fibronectin type III domain (445 - 518)

fn3

fn3: Fibronectin type III domain (533 - 608)

fn3

fn3: Fibronectin type III domain (622 - 697)

fn3

fn3: Fibronectin type III domain (710 - 786)

fn3

fn3: Fibronectin type III domain (799 - 874)

fn3

fn3: Fibronectin type III domain (888 - 962)

fn3

fn3: Fibronectin type III domain (974 - 1047)

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (1067 - 1276)

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  • 1299 a.a.
Protein Preferred Names Protein Names

tenascin-N

  • TN-N

Related Diseases

Diseases Alias
Spondyloepiphyseal Dysplasia, Nishimura Type

  • SEDN

  • Spondyloepiphyseal Dysplasia Nishimura Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14847 TNN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17047 Tro Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18901 Tnn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25392 Tnn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNN RGD RGD:1306002
Felis catus TNN VGNC VGNC:66424
Mus musculus TNN MGD MGI:2665790
Canis familiaris TNN VGNC VGNC:47685
Bos taurus TNN VGNC VGNC:36188
Macaca mulatta TNN VGNC VGNC:79359
Others TNN NCBI