PRDM15 - PR/SET domain 15 Gene

Also Known as PFM15; ZNF298; C21orf83

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63977

About PRDM15

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,798,225-41,879,344 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues, 38 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 2.4), appendix (RPKM 1.2) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

PRDM15 Products (3)

mRNA Protein Name
NM_001040424.3 NP_001035514.2 PR domain zinc finger protein 15 isoform 2
NM_001282934.2 NP_001269863.2 PR domain zinc finger protein 15 isoform 3
NM_022115.7 NP_071398.5 PR domain zinc finger protein 15 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15904895 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM15 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (738 - 760)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (765 - 785)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (826 - 848)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (853 - 875)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (904 - 924)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (929 - 951)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (992 - 1015)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1056 - 1078)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1084 - 1106)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1126 - 1150)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1154 - 1178)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1196 - 1219)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1226 - 1248)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1507 a.a.
Protein Preferred Names Protein Names

PR domain zinc finger protein 15

  • PR domain 15

Related Diseases

Diseases Alias
Galloway-Mowat Syndrome

  • Galloway Mowat Syndrome

  • Galloway Syndrome

  • Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

  • Microcephaly Nephrosis Syndrome

  • Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

  • Nephrosis Neuronal Dysmigration Syndrome

  • Microcephaly-Hiatus Hernia-Nephrotic Syndrome

  • Nephrosis-Neuronal Dysmigration Syndrome
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11065 PRDM15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRDM15 VGNC VGNC:102808
Bos taurus PRDM15 VGNC VGNC:33293
Rattus norvegicus PRDM15 RGD RGD:1310055
Mus musculus PRDM15 MGD MGI:1930121
Macaca mulatta PRDM15 VGNC VGNC:108429
Canis familiaris PRDM15 VGNC VGNC:44947
Others PRDM15 NCBI