2. Gene
  3. Popdc2 - popeye domain containing 2 Gene

Popdc2 - popeye domain containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pop2

Gene ID: 64082 | Gene type: protein coding

About Popdc2

Summary

This gene encodes a member of the Popeye domain containing family of membrane proteins. Proteins of this family contain three helical transmembrane domains and a conserved intracellular Popeye domain. In the adult mouse, this gene is expressed at high levels in cardiac myocytes, and mice deficient for this gene develop stress-induced cardiac pacemaker dysfunction. The protein binds to a two-pore domain Potassium Channel and recruits it to the plasma membrane. Cyclic adenosine monophosphate negatively regulates this interaction through the Popeye domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Popdc2 Products(2)

mRNA Protein Name
NM_001081984.2 NP_001075453.1 popeye domain-containing protein 2 isoform 1
NM_022318.3 NP_071713.1 popeye domain-containing protein 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cAMP binding IDA
IDA: Inferred from direct assay
22354168 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
22354168 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
22354168 MGI
acts upstream of or within sinoatrial node cell development IMP
IMP: Inferred from mutant phenotype
22354168 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
10882522 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

popeye domain-containing protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10879 POPDC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Popdc2 NCBI NCBI:64091