GFRA4 - GDNF family receptor alpha 4 Gene

Homo sapiens

Gene ID: 64096 | Gene type: protein coding

About GFRA4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,659,248-3,663,399 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GFRA4 Products(2)

mRNA	Protein	Name
NM_022139.4	NP_071422.1	GDNF family receptor alpha-4 isoform a precursor
NM_145762.3	NP_665705.1	GDNF family receptor alpha-4 isoform b precursor

GFRA4 Protein Structure

GDNF

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

GDNF family receptor alpha-4

GDNF receptor alpha-4

Related Diseases

Diseases

Alias

Multiple Endocrine Neoplasia

Men	Multiple Endocrine Adenomatosis
Multiple Endocrine Neoplasia Syndrome	Adenomatosis, Familial Endocrine
Endocrine Neoplasia, Multiple	Familial Endocrine Adenomatosis
Mea	Multiple Endocrine Neoplasms
Multiple Endocrine Neoplasia Type 1

Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23	SCA23
Ataxia, Spinocerebellar, Type 23

Megacolon

Dilatation Of Colon

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05389	GFRA4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GFRA4	RGD	RGD:620503
Canis familiaris	GFRA4	VGNC	VGNC:49680
Mus musculus	GFRA4	MGD	MGI:1341873
Felis catus	GFRA4	VGNC	VGNC:109566
Macaca mulatta	GFRA4	VGNC	VGNC:84886
Bos taurus	GFRA4	VGNC	VGNC:56187

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