FN3K - fructosamine 3 kinase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64122

About FN3K

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,735,615-82,751,196 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 1 paralogue. Broad expression in kidney (RPKM 47.7), brain (RPKM 22.0) and 20 other tissues.

Summary

A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]

FN3K Products (1)

mRNA Protein Name
NM_022158.4 NP_071441.1 fructosamine-3-kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein-fructosamine 3-kinase activity IDA
IDA: Inferred from direct assay
11016445 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in protein deglycation IDA
IDA: Inferred from direct assay
11522682 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FN3K Protein Structure

Fructosamin_kin

Fructosamin_kin: Fructosamine kinase (21 - 308)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

fructosamine-3-kinase

  • protein-psicosamine 3-kinase FN3K

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05014 FN3K Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FN3K MGD MGI:1926834
Macaca mulatta FN3K VGNC VGNC:72569
Felis catus FN3K VGNC VGNC:62315
Canis familiaris FN3K VGNC VGNC:54306
Rattus norvegicus FN3K RGD RGD:1559983
Bos taurus FN3K VGNC VGNC:29057
Others FN3K NCBI