Dtnbp1 - dystrobrevin binding protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 641528

Summary

Involved in several processes, including negative regulation of dendritic spine morphogenesis; positive regulation of transport; and regulation of Dopamine Receptor signaling pathway. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dtnbp1 Products (1)

mRNA Protein Name
NM_001037664.1 NP_001032753.1 dysbindin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19428785 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of dendritic spine morphogenesis IDA
IDA: Inferred from direct assay
20531346 RGD
involved in negative regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
20531346 RGD
involved in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization IMP
IMP: Inferred from mutant phenotype
15345706 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15345706 RGD
involved in positive regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
17989303 RGD
involved in regulation of dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
17989303 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
23954924 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
20531346 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
20531346 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20531346 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
19428785 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dysbindin

  • BLOC-1 subunit 8

  • biogenesis of lysosome-related organelles complex 1 subunit 8

  • distrobrevin binding protein 1

  • dysbindin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04037 DTNBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dtnbp1 NCBI NCBI:84062