Dtnbp1 - dystrobrevin binding protein 1 Gene

Rattus norvegicus

Gene ID: 641528 | Gene type: protein coding

About Dtnbp1

Summary

Involved in several processes, including negative regulation of dendritic spine morphogenesis; positive regulation of transport; and regulation of Dopamine Receptor signaling pathway. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dtnbp1 Products(1)

mRNA	Protein	Name
NM_001037664.1	NP_001032753.1	dysbindin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19428785	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	20531346	RGD
involved in negative regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	20531346	RGD
involved in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization	IMP IMP: Inferred from mutant phenotype	15345706	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15345706	RGD
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	17989303	RGD
involved in regulation of dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	17989303	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	23954924	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	20531346	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	20531346	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	20531346	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	19428785	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dysbindin

BLOC-1 subunit 8	biogenesis of lysosome-related organelles complex 1 subunit 8
distrobrevin binding protein 1	dysbindin-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04037	DTNBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dtnbp1	NCBI	NCBI:84062

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