2. Gene
  3. Fxyd4 - FXYD domain-containing ion transport regulator 4 Gene

Fxyd4 - FXYD domain-containing ion transport regulator 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Chif

Gene ID: 64190 | Gene type: protein coding

About Fxyd4

Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]

Fxyd4 Products(1)

mRNA Protein Name
NM_001368663.1 NP_001355592.1 FXYD domain-containing ion transport regulator 4 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables potassium channel activity IDA
IDA: Inferred from direct assay
7597086 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16373350 RGD
enables sodium channel regulator activity IDA
IDA: Inferred from direct assay
11483503 RGD
Biological Process GO Annotation Evidence Reference Source
involved in inorganic cation transmembrane transport IDA
IDA: Inferred from direct assay
12626497 RGD
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11181413 RGD
part of sodium:potassium-exchanging ATPase complex IDA
IDA: Inferred from direct assay
11483503 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FXYD domain-containing ion transport regulator 4

channel-inducing factor

corticosteroid-induced protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05168 FXYD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fxyd4 NCBI NCBI:53828