Herpud1 - homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Gene

Also Known as SUP; Herp; Mifl

Species: Mus musculus

Gene Type: protein coding

Gene ID: 64209

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in protein targeting to ER; regulation of ER-associated ubiquitin-dependent protein catabolic process; and regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within endoplasmic reticulum unfolded protein response; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is integral component of membrane. Is expressed in several structures, including clavicle; craniocervical region bone; early conceptus; and olfactory epithelium. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Herpud1 Products (2)

mRNA	Protein	Name
NM_001357205.1	NP_001344134.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2
NM_022331.2	NP_071726.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21600962	MGI
enables ubiquitin-like ligase-substrate adaptor activity	IMP IMP: Inferred from mutant phenotype	21600962	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	10922362	MGI
involved in protein targeting to ER	IMP IMP: Inferred from mutant phenotype	24478453	MGI
involved in regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	15147274	MGI
involved in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15147274	MGI
acts upstream of or within regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	21600962	MGI
acts upstream of or within response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	25637874	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21600962	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21600962	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15147274	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10922362	MGI
located in endoplasmic reticulum quality control compartment	IDA IDA: Inferred from direct assay	24478453	MGI
located in membrane	IDA IDA: Inferred from direct assay	10922362	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06132	HERPUD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Herpud1	NCBI	NCBI:9709