Smn1 - survival of motor neuron 1, telomeric Gene

Rattus norvegicus

Also known as Smn

Gene ID: 64301 | Gene type: protein coding

About Smn1

Summary

Enables Fibroblast Growth Factor binding activity. Involved in chemical synaptic transmission. Located in Gemini of coiled bodies; cytoplasm; and nucleolus. Human ortholog(s) of this gene implicated in Werdnig-Hoffmann disease; adult spinal muscular atrophy; intermediate spinal muscular atrophy; juvenile spinal muscular atrophy; and spinal muscular atrophy. Orthologous to several human genes including SMN2 (survival of motor neuron 2, centromeric). [provided by Alliance of Genome Resources, Apr 2022]

Smn1 Products(1)

mRNA	Protein	Name
NM_022509.2	NP_071954.2	survival motor neuron protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	12397076	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IEP IEP: Inferred from expression pattern	12030329	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Gemini of coiled bodies	IDA IDA: Inferred from direct assay	12397076	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

survival motor neuron protein

survival motor neuron 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124266	ML104		/	Unkown
HY-RS13438	SMN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22328	Smn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smn1	NCBI	NCBI:6606

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